The mission was to have conducted space walks on several occasions, using both NASA and Russian space suits.

On 2005 July 28 at 07:18 EDT the Space Shuttle mission STS-114 Orbiter docked and delivered a replacement Control Moment Gyroscope as part of the approximately 4.100 kg cargo carried inside the Multi-Purpose Logistics Module (MPLM) called Raffaello. On August 6, 2005 the Orbiter undocked from the ISS taking the MPLM back.

During the Expedition 11 mission, Russian Commander Sergei Krikalev exceeded the record for total time in space (formerly held by Sergei Avdeyev with 747.593 days). Krikalev at launch had spent 624.387 days in space. He passed the record on the 123rd day of the mission, on August 16, 2005. His cumulative time in space was 803 days and 9 hours and 39 minutes upon landing.