Expedition 48 is scheduled to be the 48th expedition to the International Space Station.

Jeffrey Williams, Aleksey Ovchinin and Oleg Skripochka are to transfer from Expedition 47. Expedition 48 is scheduled to begin upon the departure of Soyuz TMA-19M in June 2016 and conclude upon the departure of Soyuz TMA-20M in September 2016. The crew of Soyuz MS-01 are then to transfer to Expedition 49.