CRS-10 is part of the original order of twelve missions awarded to SpaceX under the CRS contract. As of June 2016, a NASA Inspector General report had this mission manifested for November 2016. The launch was put on hold pending investigation of the September 1st pad explosion, with a tentative date no earlier than January 2017, since delayed to February.

CRS-10 will be launched from Kennedy Space Center Launch Complex 39 Pad A, the first launch from the complex since STS-135 the last flight of the Space Shuttle Program, on July 8, 2011.